Home > Oncology > SABCS 2021 > Triple-Negative Breast Cancer > Early use of ctDNA testing can identify likelihood of relapse in TNBC

Early use of ctDNA testing can identify likelihood of relapse in TNBC

Presented By
Prof. Nicholas Turner, The Institute of Cancer Research, UK

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Conference
SABCS 2021
Trial
Phase 2, c-TRAK-TN
In the phase 2, proof-of-principle c-TRACK-TN trial circulating tumour DNA (ctDNA) surveillance was used in moderate or high-risk triple-negative breast cancer (TNBC) patients to start additional treatment with pembrolizumab. A substantial part of patients presenting with TNBC relapse after primary treatment. In previous retrospective findings, ctDNA detection was highly predictive for relapse in patients with TNBC who completed their primary treatment [1,2]. The prospective, multicentre, phase 2 c-TRAK-TN trial (NCT03145961) piloted the prospective use of ctDNA assays in patients treated for early-stage TNBC who were at moderate or high-risk of relapse. Prof. Nicholas Turner (The Institute of Cancer Research, UK) presented primary results of c-TRAK-TN [3]. A total of 208 patients with trackable mutations who completed surgery and adjuvant chemoth...


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