Home > Intranasal kappa-opioid agonist effective for intractable pruritus

Intranasal kappa-opioid agonist effective for intractable pruritus


Notice: Undefined index: new_doi_fields in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 138

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 138

Notice: Undefined index: new_doi_fields in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 174

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 174

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 175
Conference
AAD 2020
A case series of 16 patients with chronic itch from different underlying causes suggests that intranasal butorphanol may be highly effective with a rapid onset of action [1]. Chronic itch is a symptom frequently encountered in the dermatologic practice. Recent data suggests that generalised pruritus may result from an imbalance between the mu and kappa opioid systems. Kappa-agonists have been shown to inhibit pruritus in both animals and humans. In particular, there is a medical need for rapid-acting antipruritic agents that can disrupt the itch-scratch cycle. A case series of 16 patients with chronic, refractory pruritus from different causes investigated a nasal spray containing 10 mg/ml butorphanol. Butorphanol, a commercially available kappa-opioid agonist and mu-opioid antagonist, is approved for the management of migraine headaches, musculoskeletal pain, and post-operative pain. Patients were ≥18 years old and presented to the Johns Hopkins D...


Please login to read the full text of the article.


If you have no account yet, please register now.





Posted on