Home > Cardiology > AHA 2021 > CVD Risk Reduction > REVERSE-IT: Interim analysis shows promising effect of bentracimab on ticagrelor reversal

REVERSE-IT: Interim analysis shows promising effect of bentracimab on ticagrelor reversal

Presented By
Dr Deepak Bhatt, Brigham and Women’s Hospital, USA

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Conference
AHA 2021
Trial
Phase 3, REVERSE-IT
Bentracimab delivered immediate and sustained reversal of ticagrelor’s antiplatelet effect in patients undergoing invasive procedures or experiencing major bleeding. In addition, effective haemostasis rates were good or excellent in >90% of participants in the REVERSE-IT trial. Thus, bentracimab appears to be a promising option for ticagrelor reversal [1]. Ticagrelor is an oral P2Y12 inhibitor for patients with acute coronary syndromes. Dr Deepak Bhatt (Brigham and Women’s Hospital, MA, USA) explained that antiplatelet drugs like ticagrelor are associated with spontaneous bleeding and surgery-related bleeding. In addition, the antiplatelet effects of ticagrelor cannot be reversed by platelet transfusion. Instead, a fast-acting reversal agent is needed to reverse ticagrelor’s mechanism of action. Bentracimab is an intravenous monoclonal antibody, which has demonstrated swift and sustained reversal of ticagrelor’s antiplatelet effects in...


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