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Coronary-calcium score can help tailor treatment for severe hypercholesterolemia


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Journal
JAMA Network Open
Reuters Health – 18/02/2022 - Coronary-artery calcium (CAC) scores can help tailor treatment for adults with severely elevated low-density-lipoprotein cholesterol (LDL-C) levels, a group universally thought to be at high risk for atherosclerotic cardiovascular disease (ASCVD) events. In a large study of symptomatic adults with LDL-C of at least 190 mg/dL, the absence of CAC and noncalcified plaque was associated with a low risk of myocardial infarction, stroke and death over about four years. The findings suggest that "atherosclerosis burden, including assessment of CAC, can be used to individualize treatment intensity by identifying patients who are at low risk despite having severely elevated LDL-C levels," Dr. Martin Boedtker Mortensen with Aarhus University Hospital in Denmark and colleagues write in JAMA Network Open. U.S. and European guidelines recommend statins for all patients with severe hypercholesterolemia (LDL-C higher than 190 mg/dL) to prevent ...


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