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Elevated lipoprotein(a) linked with cardiovascular risk in patients with high coronary calcium

Journal
Journal of the American College of Cardiology
Reuters Health - 22/02/2022 - In patients with elevated coronary calcium (CAC) scores, high lipoprotein (Lp) (a) levels are independently associated with cardiovascular event risk, new research shows. The findings are drawn from longitudinal data on 4,512 participants in the Multi-Ethnic Study of Atherosclerosis and 2,078 participants in the Dallas Heart Study, all of whom were free of clinical atherosclerosis at baseline. Both studies tracked incident atherosclerotic cardiovascular disease (ASCVD) events, defined as coronary heart disease-related death, nonfatal myocardial infarction, or fatal or nonfatal stroke. The mean follow-up in both cohorts was more than a decade. Participants of the two studies were analyzed separately because Lp(a) was measured using different assays. Levels of this protein are primarily genetically determined by the age of five; American College of Cardiology/American Heart Association guidelines set 50 mg/dL as the threshold for elevated...


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