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Genetic testing for early-onset AF yields important prognostic information

Reuters Health - 12/05/2022 - Adults with early-onset atrial fibrillation (AF) often have rare genetic variants in cardiomyopathy and arrhythmia genes, and genetic testing can provide useful prognostic information, a new study suggests. Among 1,293 adults with AF diagnosed before age 66 years who underwent whole-genomic sequencing, disease-associated pathogenic or likely pathogenic (P/LP) rare variants were discovered in 131 (10%). During a median follow-up of 9.9 years, 219 adults (17%) died. In univariable analysis, having a P/LP genetic variant was associated with an increased risk of dying from any cause (hazard ratio, 1.5; 95% CI, 1.0 to 2.1; P=0.05) and the association remained significant in multivariable modeling adjusted for relevant cofactors. Other risk factors for poorer outcome included younger age at AF diagnosis, higher BMI and lower left ventricular ejection fraction (LVEF) at diagnosis. "Most patients with a history of reduced L...


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