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REBALANCE-HF: Encouraging results of GSN ablation in HFpEF

Presented By
Dr Marat Fudim, Duke Cardiology Clinic, USA
HFA 2022
Preliminary data from the REBALANCE-HF roll-in cohort demonstrated positive safety and efficacy results of splanchnic ablation for volume management (SAVM) via greater splanchnic nerve (GSN) ablation for patients with heart failure and preserved ejection fraction (HFpEF). The procedure was associated with reductions in pulmonary capillary wedge pressure (PCWP) during exercise and improvements in the health status of patients. “The splanchnic bed is the main blood volume reservoir of the body,” outlined Dr Marat Fudim (Duke Cardiology Clinic, NC, USA) [1]. “Since the activation of the sympathetic nervous system (SNS) recruits blood from this reservoir into the central circulating volume, which leads to elevation of filling pressures, ablation of the GSN may redistribute this blood to the periphery and relieve the symptoms of patients with HFpEF.” The REBALANCE-HF study (

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