Home > Cardiology > ACC/WCC 2020 > Genetics and Prevention > Higher serum levels of eicosapentaenoic acid correlate with reduced CV events

Higher serum levels of eicosapentaenoic acid correlate with reduced CV events

Presented By
Dr D. Bhatt, Brigham and Women's Hospital, USA

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Conference
ACC 2020
Trial
REDUCE-IT EPA analysis
Compared with placebo, icosapent ethyl (IPE) 4 g/day has shown to significantly reduce first and total cardiovascular (CV) events, which is beyond what can be explained by the degree of triglyceride or other biomarker changes. It seems that serum levels of eicosapentaenoic acid (EPA) play an important role here [1]. Dr Deepak Bhatt (Brigham and Women's Hospital, USA) presented the results of the REDUCE-IT EPA analysis, which was based on the initial study including 8,179 patients at 473 sites in 11 countries who had elevated CV risk and were using statins. They were randomised to IPE 2 g twice daily (n=4,089) or placebo (n=4,090) with a mean duration of 4.9 years of follow-up. Results showed that icosapent ethyl 4 grams daily compared with placebo resulted in a reduced combined rate of first and subsequent non-fatal myocardial infarction, stroke, CV deat...


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