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Inhaled flecainide promising for atrial fibrillation


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Journal
Circulation: Arrhythmia and Electrophysiology
Reuters Health - 24/03/2022 - Inhaled flecainide shows promise for returning patients with recent-onset atrial fibrillation (AF) to sinus rhythm, a new study suggests. This route of administration could shorten the duration of emergency room visits and reduce the volume of hospital admissions, they write in Circulation: Arrhythmia and Electrophysiology. "Oral and intravenous treatments require more dedicated time and specific resources from the hospital including intravenous drug infusion materials," lead author Dr. Harry J.G.M. Crijns told Reuters Health by email. "The pharmacodynamics of inhaled flecainide is different." "Inhaled flecainide converts patients to sinus rhythm at a much lower - read 'safer' - plasma concentration compared to oral or intravenous treatments," said Dr. Crijns, a cardiologist at Maastricht University Medical Center in the Netherlands. A lower concentration of flecainide is possible via inhalation because the drug is absorbed from ...


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