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Ischemic-pattern LGE in idiopathic dilated cardiomyopathy might not reflect ischemia


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Journal
Circulation: Heart Failure
Reuters Health - 30/03/2022 - A significant proportion of patients with idiopathic dilated cardiomyopathy (DCM) and late gadolinium enhancement on cardiovascular magnetic resonance (LGE-CMR) - a finding suggestive of an ischemic etiology - had no evidence of obstructive coronary artery disease on coronary angiography, investigators report. While the presence LGE- CMR abnormalities, regardless of ischemic or non-ischemic pattern, does not suggest an obstructive atherosclerotic etiology, it does not preclude the presence of either luminal or embolic or hypotensive disease for which aggressive management may still be appropriate, the researchers say. The Dilated Cardiomyopathy Precision Medicine Study evaluated the likelihood that inherited genetic abnormalities were the most common cause of DCM. Investigators excluded secondary cardiomyopathy on the basis of a detailed history and physical exams to rule out prior myocardial infarction, toxic exposure, infiltrative dis...


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