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NT-proBNP level may identify patients with non-ischemic systolic HF who might benefit from ICDs


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Reuters Health - 08/03/2022 - Patients with non-ischemic systolic cardiomyopathies who received implantable cardiac defibrillators (ICD) in a randomized trial were most likely to have a reduced risk of sudden death (SD) if their baseline level of N-terminal pro-brain natriuretic peptide (NT-proBNP) was below the median, a new analysis revealed. The findings were drawn from an extended follow-up of 1,116 participants in the DANISH Trial, in which patients with non-ischemic cardiomyopathy and ejection fraction (EF) no higher than 35% were randomly assigned to receive an ICD along with optimal medical therapy or optimal medical therapy alone. Higher NT-proBNP at baseline was associated with increased age, reduced kidney dysfunction, permanent atrial fibrillation, lower ejection fraction, worse NYHA functional class and previous hospitalization for heart failure (HF). With the median follow-up now 10 years, patients with baseline NT pro-BNP below the median value...


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