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Restrictive blood transfusion non-inferior and cost-effective strategy

Presented By
Prof. Philippe Gabriel Steg, University of Paris, Frane

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Conference
ESC 2020
Trial
REALITY trial
According to results of the REALITY trial, the largest randomised trial in this setting, restrictive blood transfusion has no negative impact on clinical outcomes compared with a more liberal strategy in anaemic patients with an acute myocardial infarction (AMI) [1]. Incidence rates of infections and acute lung injury were lower with the restrictive strategy. The optimal transfusion strategy in anaemic patients with AMI is unclear. Observational studies have reported that blood transfusion may be associated with a higher mortality rate in patients with AMI, and only 2 small randomised trials have been conducted, with conflicting results. The REALITY trial enrolled 666 patients (mean age 77 years; 43% female) with AMI and haemoglobin (Hgb) 8-10 g/dL during admission, who were randomised to either a liberal or restrictive red blood cell (RBC) transfusion strategy. In the restrictive strateg...


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