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TTR gene variant ups risk of heart failure among Black individuals


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Journal
JAMA
Reuters Health - 05/04/2022 - The risk of heart failure is increased in Black carriers of the transthyretin (TTR) Val122Ile mutation, the genetic basis of hereditary transthyretin amyloidosis cardiomyopathy (hATTR-CM), a new study shows. "Although the study findings indicate a robust association of the TTR Val122Ile variant with incident heart failure, it is unlikely to account for much of the excess heart failure risk experienced by Black individuals," the authors caution in their JAMA paper. "The TTR Val122Ile variant may only partly contribute to the relatively higher prevalence of heart failure among Black individuals, which may predominantly result from adverse environmental factors (lifestyle and clinical factors, systemic racism, and social determinants of health)," they write. Dr. Pankaj Arora of the University of Alabama Birmingham and colleagues sought to quantify the association of the TTR Val122Ile variant with incident heart failure and mortality...


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