Home > Dermatology > AAD 2022 > What’s Hot in Rare Diseases > Innovative gel speeds up clearance of molluscum contagiosum lesions

Innovative gel speeds up clearance of molluscum contagiosum lesions

Presented By
Prof. John Browning, University of Texas, USA
Presented by
John Browning
AAD 2022
Phase 3, B-SIMPLE4
A nitric oxide (NO)-releasing gel consisting of 2 components showed to be effective against molluscum contagiosum (MC). In the pivotal phase 3 B-SIMPLE4 trial, almost a third of patients achieved complete clearance of all skin lesions after 12 weeks of treatment with the berdazimer 10.3% gel. MC is a viral infection that primarily affects children and for which no approved treatment currently exists. It is caused by a poxvirus and is characterised by small, round, firm, umbilicated, often painless bumps [1]. Although usually harmless and self-limited, possible psychosocial complications can include stigma, disfiguring lesions, and scars. In addition, MC can take a long time to resolve, ranging from 13 months to 4 years [2,3]. At present, up to 73% of children with MC go untreated [4]. NO is an endogenous small molecule (gas) with several diverse physiological, cellular, and molecular functions. It modulates many physiological functi...

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