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Higher risk of severe cardiovascular events seen in months after starting ustekinumab therapy


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Journal
JAMA Dermatology
Reuters Health - 15/09/2020 - The odds of experiencing a severe cardiovascular event are increased in the months following the start of ustekinumab treatment in patients with high cardiovascular risk, according to a database study. Interleukin(IL)-23, which along with IL-12 is blocked by ustekinumab, appears to protect against atherosclerotic plaque growth and vulnerability. An earlier meta-analysis of clinical trials of patients with moderate to severe psoriasis suggested a possible excess of major adverse cardiovascular events among those treated with ustekinumab and briakinumab. Dr. Alain Dupuis of Centre Hospitalier Universitaire Rennes, in France, and colleagues used data from the French national health-insurance database to investigate whether ustekinumab treatment is indeed associated with severe cardiovascular events (acute coronary syndrome with hospitalization in the intensive-care unit or ischemic stroke with hospitalization in any department) during the ...


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