Home > Dermatology > Melanoma-secreted amyloid beta likely curbs neuroinflammation, promotes brain metastases

Melanoma-secreted amyloid beta likely curbs neuroinflammation, promotes brain metastases


Notice: Undefined index: new_doi_fields in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 138

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 138

Notice: Undefined index: new_doi_fields in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 174

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 174

Notice: Trying to access array offset on value of type null in /home/daan/projects/medicalconferences_dev/wp-content/themes/writers-blogily-child/functions.php on line 175
Journal
Cancer Discovery
Reuters Health - 15/03/2022 - Amyloid beta, a protein that builds up in the brains of patients with Alzheimer's disease, was shown in preclinical studies to promote brain metastases in melanoma and ramp down immune responses. In addition, a beta secretase inhibitor significantly reduced the amount of brain melanoma metastases in mice. "We were surprised to find that proteins related to neurodegenerative disorders, such as Alzheimer's and Parkinson's disease, were differentially expressed in melanoma cells, suggesting a mechanistic link between brain cancer and neurodegeneration," Dr. Kevin Kleffman of NYU Grossman School of Medicine in New York City told Reuters Health by email. "The discovery suggests that there may be shared pathologic features of these seemingly unrelated devastating diseases," he said. "Further investigation into this connection may yield important insights about both." As reported in Cancer Discovery, Dr. Kleffman and colleagues c...


Please login to read the full text of the article.


If you have no account yet, please register now.





Posted on