Home > Dermatology > PFGC 2021 > Comorbidity in Psoriasis > Comorbidity and clinical features of psoriasis vary according to HLA-C*06:02 status

Comorbidity and clinical features of psoriasis vary according to HLA-C*06:02 status

Presented By
Dr Ravi Ramessur, King’s College London, UK

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Conference
PFGC 2021
A British cross-sectional investigation found that HLA-C*06:02-positive patients were more likely women and younger at diagnosis of psoriasis. Genetic effects on comorbid body weight were also different between the sexes [1]. Carrying the HLA-C*06:02 allele has been linked to certain features of psoriasis, such as early onset of disease, severe disease, guttate psoriasis, and differential response to therapy with biologics in the past [2–5]. “We, therefore, set out to systematically evaluate and further characterise differences between HLA-C*06:02 positive and negative psoriasis,” Dr Ravi Ramessur (King’s College London, UK) said [1]. To do so, data of people with European ancestry was analysed from 2 British cross-sectional databanks: the Biomarkers of Systemic Treatment Outcomes in Psoriasis (BSTOP) and the UK Biobank [1,2]. BSTOP is an observational study of severe psoriasis containing clinical and genotype data from more than 70 dermatology centres in ...


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