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TNF inhibitor for immune-mediated inflammatory disease doubles the risk of paradoxical psoriasis

Presented By
Dr Nikolai Loft, Copenhagen University Hospital, Denmark

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Conference
PFGC 2021
According to a Danish cohort study, patients with immune-mediated inflammatory disease treated with a tumour necrosis factor-alpha (TNFα) inhibitor had a 2-fold increased risk of new-onset psoriasis compared with those receiving conventional therapy. The risk to develop pustular psoriasis was 3 times higher compared with patients treated with a non-TNF biologic.  Some patients with immune-mediated inflammatory disease develop paradoxical induction or worsening of psoriasis during treatment with TNFα inhibitors. As this side effect is poorly understood, a Danish cohort study explored the risk of new-onset psoriasis during treatment with a TNF inhibitor compared with the risk during treatment with non-biologic conventional treatment [1]. Dr Nikolai Loft (Copenhagen University Hospital, Denmark) and colleagues evaluated the risk of developing any type of psoriasis, non-pustular and pustular psoriasis. Data was derived from the Danish national registries, whic...


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