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Radiomic signature may predict survival in pembrolizumab-treated advanced melanoma


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Journal
JAMA Oncology
Reuters Health - 25/01/2022 - In patients with advanced melanoma treated with pembrolizumab monotherapy, a radiomic signature derived from baseline computed tomography (CT) images may predict overall survival (OS), researchers suggest. There is a "critical need" for early radiographic markers for metastatic melanoma treated with immune checkpoint inhibitors such as pembrolizumab, because of atypical responses - e.g., pseudoprogression - to these drugs, Dr. Laurent Dercle of Columbia University Medical Center in New York City told Reuters Health by email. "The most striking result of our study was that the signature could be used to identify pseudoprogressors, since it estimated a favorable outcome and a favorable overall survival in 82% of patients whose tumors were categorized as pseudoprogression at month 3," he said. "We previously found that similar features could be used in patients with lung cancers and colorectal cancers." In non-small cell lung cancer...


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