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Therapeutic lymph node dissection may not be needed in melanoma when index node responds


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Journal
JAMA Surgery
Reuters Health - 15/02/2022 In patients with high-risk melanoma who show a robust response to neoadjuvant checkpoint inhibition in the index lymph node (ILN), a therapeutic lymph node dissection (TLND) may be omitted, a retrospective study suggests. "The take-home message at the moment is that melanoma surgeons should talk to their breast cancer surgeon colleagues to prepare themselves for this likely upcoming new approach of surgery in stage III melanoma," Dr. Christian Blank of The Netherlands Cancer Institute in Amsterdam told Reuters Health by email. "The PRADO trial (https://bit.ly/3gLFZLo) results that we hope to present at ASCO 2022 this June prospectively tested the ILN procedure, using the results to de-escalate in good responders and to escalate therapy in non-responders," he said. Dr. Blank and colleagues note in JAMA Surgery that neoadjuvant checkpoint inhibition in patients with ...


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