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Antibiotics plus oral fecal microbiota transplantation tied to ulcerative colitis remission


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Journal
Lancet Gastroenterology and Hepatology
Reuters Health - 24/12/2021 - In patients with active ulcerative colitis (UC), antibiotics followed by oral lyophilized fecal microbiota transplantation (FMT) was associated with induction of remission in a small placebo-controlled trial in Australia. "We were surprised by the magnitude of improvement with oral FMT, (which) appeared to be independent of the patients' current treatment," Dr. Rupert Leong of Concord Repatriation General Hospital in New South Wales and the University of Sydney told Reuters Health by email. "Patients not only benefited symptomatically, but at 56 weeks those randomized to continue FMT demonstrated not only endoscopic remission, but histologic remission as well," he said. "Perhaps manipulation of the intestinal microbiome might improve the efficacy of conventional treatments. His team randomly assigned 35 UC patients (median age, 37; about 50% women overall) to receive oral lyophilized FMT (15 patients) or placebo for eight weeks. ...


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