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Crohn’s strictures may respond to immunosuppressive drug therapy


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Journal
Lancet Gastroenterology & Hepatology
Reuters Health - 31/12/2021 - Symptomatic strictures related to Crohn's disease (CD) may respond to immunosuppressive drug therapy, with improvements in symptoms and stricture morphology, according to results of a study from Australia. "This study shows that Crohn's disease-associated bowel wall damage, characteristic of inflammatory strictures, is potentially reversible with drug treatment," the study team reports in The Lancet Gastroenterology & Hepatology. "Combination immune suppression with treat-to-target treatment escalation based on objective measures of persistent inflammation provided better outcomes than did standard drug therapy," they add. Strictures are the most common structural complication of CD, and surgery and endoscopic balloon dilation are the chief treatment options. Drug therapy has been considered contraindicated, note Dr. Julian Schulberg of St. Vincent's Hospital, in Melbourne, and colleagues. The STRIDENT study is believe...


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