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Early introduction of gluten might prevent celiac disease


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Journal
JAMA Pediatrics
Reuters Health - 30/09/2020 - Introduction of high-dose gluten consumption beginning at age 4 months may be able to help prevent celiac disease (CD), a randomized clinical trial suggests. Earlier studies have found no effect of early introduction of gluten on the risk of developing CD, but those studies used a gluten dose of only 0.7 g/week, note Dr. Gideon Lack of King's College London and colleagues in JAMA Pediatrics. In the Enquiring About Tolerance (EAT) study, the researchers compared exclusive breastfeeding with introduction of six allergenic foods, including gluten at 3.2 g/week, alongside breastfeeding to infants' diets from age 4 months. The current analysis includes 1,004 children who were tested for anti-transglutaminase type 2 (TG2) antibodies at age 3 years. The median age at gluten introduction was 4 months in the early-introduction group versus 7 months in the control group. Between ages 4 and 6 months, the mean gluten consumption was 2.66 g/w...


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