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Multi-Omic and dietary analysis of Crohn’s disease identifies pathogenetic factors

Presented By
Dr Yael Haberman, Sheba Medical Center, Israel

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Conference
ECCO 2022
Dietary differences between participants with Crohn’s disease (CD) at diagnosis and healthy controls were observed in an analysis of the Israelian Sheba cohort. The consumption of vitamin D, olive oil, and vegetables was reduced in participants with CD, whereas their sugar, starch, and nitrite intake was increased in this group. Moreover, integration between dietary and transcriptomics, metabolomics, and the microbiome revealed novel pathogenetic factors. Dr Yael Haberman (Sheba Medical Center, Israel) and colleagues aimed to decipher dietary, environmental, and host factors that drive the increasing incidence of CD [1]. For this purpose, they collected dietary, transcriptomic, metabolomic, environmental, and microbial data from 25 participants with CD at CD diagnosis and 33 healthy controls. The dietary analysis showed that vitamin D, olive oil, and vegetable intake was significantly lowerd in participants with CD compared with healthy controls. In...


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