Home > Gastroenterology > ECCO 2022 > Novel Treatment Modalities > Mirikizumab efficacious for active ulcerative colitis

Mirikizumab efficacious for active ulcerative colitis

Presented By
Prof. Geert D’Haens, Amsterdam University Medical Center, the Netherlands

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Conference
ECCO 2022
Trial
Phase 3, LUCENT-1
Mirikizumab was more efficacious than placebo as induction therapy for participants with moderately to severely active ulcerative colitis (UC). In addition, mirikizumab showed a favourable safety profile. These results from the phase 3 LUCENT-1 trial support the applicability of mirikizumab in patients with UC. Mirikizumab is an IgG4 monoclonal antibody targeting IL-23. In a phase 2 study (NCT02589665), this agent outperformed placebo in participants with active UC. The multicentre, double-blind, phase 3 LUCENT-1 trial (NCT03518086) randomised participants with moderately to severely active UC, who failed on at least 1 prior therapy, to mirikizumab (n=868) or placebo (n=294). Participants in the experimental arm received 300 mg mirikizumab intravenous, at weeks 0,...


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