Home > Gastroenterology > p53 mRNA nanotherapy plus anti-PD-1 therapy reverse immunosuppression in a liver cancer model

p53 mRNA nanotherapy plus anti-PD-1 therapy reverse immunosuppression in a liver cancer model


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Journal
Nature Communications
Reuters Health -  23/02/2022 - Combining p53 nanotherapy with anti-PD-1 immunotherapy reversed immunosuppression and improved anti-tumor activity compared to either therapy alone in a mouse model of liver cancer, a proof-of-concept study shows.  "Our... results suggest that this new combinatorial approach could be transformative for treating hepatocellular cancer (HCC) and possibly other cancers with loss of p53 function," Dr. Jinjun Shi of Brigham and Women's Hospital and Dr. Dan Duda of Massachusetts General Hospital told Reuters Health by email.  "The tumor suppressor gene p53 is widely mutated in many cancers, yet effectively restoring its function for canc...


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