Home > Gastroenterology > Upadacitinib may best biologics for clinical remission of ulcerative colitis

Upadacitinib may best biologics for clinical remission of ulcerative colitis


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Reuters Health - 06/01/2022 - A new network meta-analysis suggests that the selective JAK inhibitor upadacitinib ranks first with respect to clinical remission and response among ulcerative colitis (UC) treatments, although more head-to-head trials are needed, researchers say. "Two previous network meta-analyses both showed infliximab was ranked first for all endpoints (clinical remission, endoscopic improvement, and clinical response) in moderate-to-severe UC," Dr. Alexander Ford of the University of Leeds, UK told Reuters Health by email. "Given that drug has been around for >20 years, that would seem 'disappointing' in terms of its superiority to novel therapies." "In this new network meta-analysis, upadacitinib came first across almost all endpoints," he said. "Infliximab was still top for endoscopic improvement, but not when trials were subgrouped according to whether they recruited TNF-naïve or -exposed patients; in those two subgroup analyses, again upadac...


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