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10-year leukemia remissions credited to CAR T-cell persistence


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Journal
Nature
Reuters Health - 10/02/2022 - Two patients with chronic lymphocytic leukemia (CLL) have achieved 10-year remissions after treatment with chimeric antigen receptor (CAR) T-cells, a report in Nature reveals. "This duration and level of persistence of second-generation CAR T-cell has not been observed before," Dr. J. Joseph Melenhorst of the Perelman School of Medicine, University of Pennsylvania in Philadelphia, told Reuters Health by email. "We demonstrate that individual CAR T-cells/CAR T-cell clones expanded, cleared the leukemia, and maintained activity for such a long time," he said. "This means that the memory function of immune cells, the very same principle at the heart of vaccinations against common and emerging viruses etc., apply to CAR T-cells also." "We noted that while the initial anti-leukemia CAR T-cell population constituted predominantly killer cells with CD4-positive T cells trailing in the shadows, this latter population was in fact the one ...


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