Home > Haematology > Allogenic HCT using younger, unrelated donors may help curb relapse in myelodysplastic syndrome

Allogenic HCT using younger, unrelated donors may help curb relapse in myelodysplastic syndrome


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Journal
JAMA Oncology
Reuters Health - 21/01/2022 - For patients with myelodysplastic syndrome (MDS), using younger human leukocyte antigen-matched unrelated donors (MUDs) for allogenic hematopoietic cell transplantation (allo-HCT) was associated with better outcomes than using older matched sibling donors (MSDs) in a retrospective study. "MDS is a disease of older adults and if they have a matched sibling donor available, the donor is also likely to be older and have issues from aging," Dr. Guru Subramanian Guru Murthy of the Medical College of Wisconsin in Milwaukee told Reuters Health by email. "When an older MSD and a younger MUD are available as options, clinicians wonder if one is a better donor than the other, and the usual choice is an MSD." Yet, the study found that younger MUDs were associated with "significantly lower risk of relapse and superior disease-free survival, suggesting this to be a potential way to minimize relapse of MDS after transplant," he noted. "We suspect tha...


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