Home > Haematology > ASH 2021 > Acute Myeloid Leukaemia > Encouraging results of novel triplet combination for AML

Encouraging results of novel triplet combination for AML

Presented By
Dr Patrick Reville, MD Anderson Cancer Center, TX, USA

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Conference
ASH 2021
Trial
Phase 2
A regimen of cladribine plus low-dose cytarabine plus venetoclax alternated with 5-azacitidine plus venetoclax showed encouraging efficacy in patients with newly diagnosed acute myeloid leukaemia (AML). Moreover, the displayed efficacy was consistent across European LeukemiaNet (ELN) risk groups and patients ≥70 years of age. The results of this phase 2 trial need to be confirmed in larger trials but are really very promising [1]. Dr Patrick Reville (MD Anderson Cancer Center, TX, USA) and colleagues included patients with newly diagnosed AML of ≥60 years of age to evaluate a regimen of cladribine plus low-dose cytarabine plus venetoclax, alternating with 5-azacitidine plus venetoclax. Participants (n=60) followed 1 or 2 cycles (28 days per cycle) of induction therapy (cladribine, 5 mg/m2, once daily on day 1 to 5; cytarabine, 20 mg, twice daily on day 1 to 10; venetoclax, 100 mg, 200 mg, or 400 mg [dose ...


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