Home > Haematology > ASH 2021 > Acute Myeloid Leukaemia > Heavily pre-treated FLT3-mutated AML population may benefit from novel triplet regimen

Heavily pre-treated FLT3-mutated AML population may benefit from novel triplet regimen

Presented By
Dr Musa Yilmaz, MD Anderson Cancer Center, TX, USA

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Conference
ASH 2021
A combination treatment of quizartinib plus venetoclax plus decitabine was highly active in patients with relapsed/refractory FLT3-ITD-mutated acute myeloid leukaemia (AML). Patients with RAS/MAPK and FLT3-F691L mutations displayed more often treatment resistance. The safety profile of this combination did not show unexpected issues [1]. FLT3 mutations in AML are associated with an increased risk of relapse and a reduced overall survival. Although FLT3 inhibitors plus intensive chemotherapy may improve outcomes in younger patients, older or unfit patients continue to display poor outcomes. Dr Musa Yilmaz (MD Anderson Cancer Center, TX, USA) and colleagues designed a trial to investigate a triplet combination regimen of quizartinib, decitabine, and venetoclax in relapsed/refractory FLT3-mutated patients with AML (n=23) or newly diagnosed FLT3-mutated patients who were unfit for intensive chemoth...


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