Home > Haematology > ASH 2021 > Lymphoma > Novel non-invasive biomarker ctDNA shows value in CNS lymphoma

Novel non-invasive biomarker ctDNA shows value in CNS lymphoma

Presented By
Dr Jurik Mutter, University Medical Center Freiburg, Germany

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Conference
ASH 2021
Circulating tumour DNA (ctDNA) was associated with progression-free survival (PFS) and overall survival (OS) in patients with central nervous system (CNS) lymphoma. Moreover, the ultrasensitive and robust detection of ctDNA in patients with different disease severity suggested accurate reflection of tumour burden, thereby supporting the potential of this biomarker as a decision-making tool in clinical practice [1]. Selecting patients at high risk for treatment failure is an unmet need in the management of patients with CNS lymphoma. Moreover, the invasive neurosurgical methods that are currently used for the diagnosis of this disease carry risks and require an adequate fitness level of the patient. ctDNA is a promising, non-invasive biomarker for patients with systemic lymphoma. Dr Jurik Mutter (University Medical Center Freiburg, Germany) and colleagues assessed the potential of ctDNA in CNS lymphoma through Cancer Personalised Profiling by Deep Sequencin...


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