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Persistent disparities in ALL health outcomes

Presented By
Dr Sumit Gupta, University of Toronto, Canada
ASH 2021
Significant disparities in health outcomes were observed across race, ethnicity, and socioeconomic status (SES) in patients with acute lymphoblastic leukaemia (ALL). Differences in leukaemia biology or disease prognosticators do not account for the full magnitude of these disparities. The Children’s Oncology Group (COG) ALL committee is aiming to unravel the underlying mechanisms and to design interventions targeting the reported disparities [1]. Dr Sumit Gupta (University of Toronto, Canada) and colleagues investigated 24,979 patients with ALL, ranging from 0–31 years of age, who were enrolled in COG frontline ALL trials between 2004 and 2019, to study health outcomes across race, ethnicity, SES, and disease prognosticators. SES was inferred by insurance status. The main outcomes were event-free survival (EFS) and overall survival (OS). Change in estimate approach was used to evaluate the relative contribution of race, ethnicity, SES, and disease prognost...

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