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Clot-busting drugs appear safe in stroke patients taking blood thinners


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Journal
JAMA
Reuters Health - 14/02/2022 - Adults taking a non-vitamin K antagonist oral anticoagulant (NOAC) who suffer ischemic stroke can safely be treated with intravenous thrombolytic therapy, with no increased risk of bleeding, according to a real-world analysis. The results run counter to current guidelines that recommend against use of IV tissue plasminogen activator (alteplase) in patients who suffer a stroke while on a NOAC, say the authors of the study published in JAMA with simultaneous presentation at the International Stroke Conference. The author of a JAMA editorial says this study provides "important data" that begins to fill an evidence gap and helps define the safety of IV alteplase among patients taking NOACs. For their study, Dr. Ying Xian with UT Southwestern Medical Center in Dallas and colleagues identified 163,038 patients with acute ischemic stroke treated with IV alteplase at 1,752 U.S. hospitals participating in the Get With the Guidelines-Strok...


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