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Orthostatic hypertension in younger hypertensives a predictor of adverse outcomes


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Reuters Health - 28/03/2022 -Young to middle-age adults with Stage 1 hypertension whose systolic blood pressure rises with standing are at increased risk for adverse cardiovascular and renal events over the long term, researchers say. Early pharmacologic intervention may be appropriate for young hypertensive patients with a hyperreactive BP response to standing, according to their report in Hypertension. The findings are drawn from the longitudinal HARVEST study, in which 1,207 subjects ages 18 to 45 (mean age, 33; 72% male) were identified with untreated Stage 1 hypertension (systolic BP 140-159 mmHg and diastolic BP 90-99 mmHg). At the start, study participants underwent three sets of supine and standing orthostatic BP measurements on two occasions separated by two weeks, in addition to 24 hour ambulatory BP monitoring. Participants were then followed with office BP measurements at regular intervals; if BP remained above guideline limits despite nonpharmaco...


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