Home > Neurology > AAN 2022 > Alzheimer’s Disease and Other Dementias > Cardiorespiratory fitness protects against dementia

Cardiorespiratory fitness protects against dementia

Presented By
Dr Edward Zamrini, Washington DC VA Medical Center, DC, USA
Presented by
Edward Zamrini Washington DC VA Medical Center
AAN 2022
In a large, prospective study, high cardiorespiratory fitness lowered the risk of developing Alzheimer’s disease (AD) and related disorders (ADRD). The association was inverse, independent, and graded: the highest-fit group had the lowest ADRD risk, the lowest-fit group the highest. Cardiorespiratory fitness is associated with favourable health outcomes, but the impact on the risk of incident AD/ADRD is unknown [1]. This relationship was examined in 649,605 military veterans in the Veterans Health Administration database who completed a standardised exercise treadmill test between 2000 and 2017 and did not have ADRD at that time [2]. Participants were aged between 30 and 95 years (average age: 61 years); 5.7% were women and 16.6% African Americans. Based on peak metabolic equivalents (METs) during the first exercise treadmill test, they were differentiated into 5 age-specific fitness categories: lowest-fit (n=132,634; METs=3.8), low-fit (n=129,49...

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