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New evidence for biological basis of “COVID-19 brain fog”

Presented By
Dr Joanna Hellmuth, University of California, CA, USA
Presented by
Joanna Hellmuth University of California
AAN 2022
Most patients with cognitive post-acute sequelae of SARS-CoV-2 infection (PASC) who had mild COVID-19 symptoms had elevated levels of CSF immune activation and immunovascular markers compared with controls. These findings confirm the hypothesis that the condition often referred to as “brain fog” has a neurological (as opposed to psychological) basis and is linked to immune dysfunction. Initial findings of the presented study were published in early 2022, in which the authors reported a high rate (77%; 10/13) of cognitive PASC patients with a CSF abnormality on clinically available tests versus 0% (0/4) of cognitive controls [1]. To further clarify how to identify patients with cognitive PASC and its biological correlates, 23 patients were followed who presented with new, persistent, cognitive PASC while recovering from relatively mild SARS-CoV-2 infection not requiring hospitalisation [2]. Ten recovering patients without PASC served as a control ...

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