Home > Neurology > AAN 2022 > Cerebrovascular Disease and Stroke > Plasma NfL levels associated with cardiovascular risk

Plasma NfL levels associated with cardiovascular risk

Presented By
Dr Hugo Aparicio, Boston University School of Medicine, MA, USA
Presented by
Hugo Aparicio Boston University
AAN 2022
Elevated levels of neurofilament light chain (NfL) are a known biomarker for neurodegeneration in conditions such as stroke, dementia, multiple sclerosis, and amyotrophic lateral sclerosis. A new study revealed that NfL may also be a risk marker for the onset of cardiac disease. Circulating NfL levels were found to be associated with future risk of all cardiovascular diseases, coronary heart disease, and heart failure, but only in minimally adjusted models. To determine whether NfL is a risk marker for future cardiovascular disease, Dr Hugo Aparicio (Boston University School of Medicine, MA, USA) and colleagues determined plasma NfL levels of 2,048 participants in the community-based Framingham Heart Study Offspring and OMNI1 cohorts using a high-sensitivity, single-molecule array [1]. Mean age was 69 years, and 58% were women. All models were adjusted for age, sex, and cohort. During the study period (2011–2019), 175 (8.5%) incident cardi...

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