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Alzheimer’s-like changes seen in COVID-19 patients’ brains


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Journal
Alzheimer's & Dementia; bioRxiv; Preprints with The Lancet
Reuters - 04/02/2022 - People who die of severe COVID-19 have brain abnormalities that resemble changes seen in Alzheimer's disease, small studies have found. These changes include accumulation of a protein called tau inside brain cells, and abnormal amounts of the protein beta-amyloid that accumulates into amyloid plaques.  At Columbia University, Dr. Andrew Marks and colleagues studied the brains of 10 COVID-19 patients and found defects in proteins called ryanodine receptors that control the passage of calcium into cells. In Alzheimer's disease, defective ryanodine receptors are linked to accumulation of tau into so-called neurofibrillary tangles. These tangles were present in high levels in the COVID-19 patients' brains, the Columbia team reported in Alzheimer's & Dementia


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