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Biomarker in platelets may pinpoint depression, treatment response


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Journal
Molecular Psychiatry
Reuters Health - 09/02/2022 - The activity of a specific G protein that is "stuck" in platelets of patients with major depression could serve as a biomarker for the disorder and response to antidepressant therapy, a proof-of-concept study suggests.  "My colleagues and I have been studying G protein signaling in the nervous system for the past 40 years," Dr. Mark Rasenick of the University of Illinois at Chicago told Reuters Health by email. "We (did) a series of preclinical studies in rodents and cultured cells showing that a signature of antidepressant action is the increased efficiency of a particular G protein, Gsalpha. The first paper on this was published by David Menkes and me in 1983." (https://bit.ly/3s...


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