New direct oral anticoagulants (DOACs), of which edoxaban is an example, are recommended for stroke prevention in NVAF patients. SATES was a prospective study to evaluate the safety of initiation within 72 hours of full dose edoxaban in NVAF patients after acute ischaemic stroke. The primary endpoint was safety in terms of any major bleeding in the first 3 months of treatment. Secondary endpoints were incidence of major bleeding, haemorrhagic transformation, and symptomatic haemorrhagic transformation rate, 3±2 days after the start of edoxaban treatment.
A total of 50 patients were enrolled, with a mean age of 77 years and a mean NIH Stroke Scale/Score of 7.8. After 3 months, only one major bleeding (gastrointestinal bleeding) was reported, which resulted in a temporary suspension of edoxaban use; there were also 8 minor bleedings, without recurrence of stroke. There was no major bleeding or symptomatic haemorrhagic transformation in the first 3±2 treatment days; the incidence rate of haemorrhagic transformation was 12% for haemorrhagic infarction (HI)-1 (small petechiae) and 8% for HI-2 (confluent petechiae) without neurological deterioration. All patients continued edoxaban after 3 months.
- Frisullo G, et al. Abstract O1031, EAN 2020.
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Table of Contents: EAN 2020
Featured articles
Alzheimer's Disease and Other Dementias
Non-Alzheimer’s disease pathophysiology in the elderly
Novel genetic association with resistance to ERC tau deposition
Diastolic dysfunction novel risk factor for cognitive impairment
Epilepsy
Avoidable epilepsy-related mortality remains high
How genetic testing can contribute to epilepsy management
Cenobamate effective in focal epilepsy
Sustained seizure reductions with cannabidiol for Lennox-Gastaut syndrome
Prevalence of autoantibodies in epilepsy almost 10%
Parkinson's Disease
White matter matters in Parkinson’s disease
Sleep disorders mark PD progression
Directional DBS superior to omnidirectional DBS
Stroke
Benefits of statins to prevent stroke outweigh risks
Extubation after thrombectomy: the sooner, the better
Thrombus location and length predictors of early neurological deterioration
Endovascular treatment in large vessel occlusion stroke patients treated with OAC
Early edoxaban may be safe after cardioembolic stroke
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