Home > Neurology > Fragmented sleep in aging traced to over-sensitive neurons

Fragmented sleep in aging traced to over-sensitive neurons


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Journal
Science
Reuters Health - 15/03/2022 - A type of neuron in the hypothalamus that regulates transitions between sleep and wakefulness becomes "hyperexcitable" with age, lowering the threshold that triggers it to fire and rouse the rest of the brain, a study in mice shows.  In older animals, hypocretin neurons - which secrete neuropeptides, known as hypocretins or orexins, that promote wakefulness - were diminished in number and often in a partly active state, requiring less stimulation to fire, researchers found in a series of experiments.  They traced the older neurons' hyperexcitability t...


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