Home > Neurology > EAN 2020 > Headache and Pain > Fremanezumab tolerability in cardiovascular patients with migraine

Fremanezumab tolerability in cardiovascular patients with migraine

Presented By
Dr Gianluca Coppola, Sapienza University of Rome, Italy

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Conference
EAN 2020
Trial
Phase 3, HALO, FOCUS
In a pooled analysis of 3 phase 3 trials, fremanezumab treatment over 12 weeks was well tolerated, with a low rate of cardiovascular adverse events (AEs) similar to placebo in migraine patients using cardiovascular medication at baseline [1]. There were no new safety signals over 12 weeks of double-blind treatment. Fremanezumab is a a fully-humanised monoclonal antibody that selectively targets calcitonin gene-related peptide. The 3 trials included were HALO EM, HALO CM, and FOCUS, in which patients were randomised to subcutaneous quarterly or monthly fremanezumab, or placebo over 12 weeks. Overall, 280/2,842 trial participants were receiving car...


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