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Gold nanocrystals may improve brain metabolic profile


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Conference
MS Virtual 2020
Trial
REPAIR-MS, REPAIR-PD, VISIONARY-MS
Interim results from two phase 2 studies provide evidence that orally delivered CNM-Au8 (gold nanocrystals) have catalytic effects on key bioenergetic metabolites in the brain of patients with MS or Parkinson's disease (PD) [1]. The observed metabolic homeostasis may be neuroprotective. CNM-Au8 is a suspension of clean-surfaced, faceted, gold nanocrystals that promotes remyelination and neuroprotection by catalysing nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP) production and by reducing oxidative stress. Treatment effects are evaluated using high-resolution 31P-magnetic resonance spectroscopy (31P-MRS). With this quantitative technique, bioenergetic metabolites can be monitored, as well as phospholipid and myelin precursors. Preliminary target engagement data from 2 ongoing open-label imaging trials were presented:


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