Home > Neurology > LRRK2 mutations drive iron accumulation in genetic Parkinson’s disease

LRRK2 mutations drive iron accumulation in genetic Parkinson’s disease


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Journal
PLOS Biology
Reuters Health - 23/12/2021 - Mutations in LRRK2 seem to drive the mislocation and accumulation of toxic iron in the brains of individuals with genetic Parkinson's disease (PD), researchers suggest. Mutations in LRRK2 account for about 5% of all cases of familial PD and about 1% on non-familial cases. "We describe a series of molecular links between a known cause of Parkinson's disease, LRRK2 mutations, with changes in iron metabolism in the context of inflammation," Dr. Mark Cookson of the US National Institute on Aging, National Institutes of Health in Maryland told Reuters Health by email. "It has been known for some time that inflammation and iron accumulation occur in the Parkinson's brain but our study is the first to outline the specific links to LRRK2." "One area that was surprising was that we saw such clear-cut effects of mutations when we looked in the mouse model," he said. "These animals generally don't show phenotypes so being able induce strong...


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