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MRI shows promise in diagnosing chronic traumatic encephalopathy


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Journal
Alzheimer's Research & Therapy
Reuters Health - 24/12/2021 - MRI shows promise in helping doctors diagnose chronic traumatic encephalopathy (CTE) in living patients, according to a new case study. To date, the progressive brain disease associated with repeated head impacts and found in athletes, military personnel, and victims of physical abuse, is diagnosed only after death. "Cognitively symptomatic male brain donors with autopsy-confirmed CTE had more severe visually rated frontal, temporal, and hippocampal atrophy and increased odds for having a CSP (cavum septum pellucidum) on antemortem MRI scans compared to same-age men with NC (normal cognition). In addition, more severe p-tau pathology was associated with greater MRI ratings of atrophy," Dr. Jesse Mez of Boston University and colleagues write in Alzheimer's Research & Therapy. "If validated with prospective clinical-pathological correlation studies, these findings support the use of structural MRI as a valuable tool to support ...


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