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Post-traumatic amnesia, chronic vascular lesions risk factors for Alzheimer’s after TBI


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Journal
Alzheimer Disease & Associated Disorders
Reuters Health - 06/01/2022 - Post-traumatic amnesia and chronic vascular lesions appear to be risk factors for developing Alzheimer's disease (AD) following traumatic brain injury (TBI), which could help optimize care following TBI, report researchers in Canada. TBI is increasingly recognized as a major risk factor for developing neurocognitive disorders, triggering neurodegeneration through various mechanisms, Dr. Elaine de Guise of the University of Montreal and colleagues note in their report in Alzheimer Disease & Associated Disorders. Determining risk factors for post-traumatic neurodegeneration in TBI patients is "critical given the high incidence of TBI," the team writes. They hypothesized that cardiovascular and metabolic comorbidities, in addition to TBI severity, would be associated with the risk of post-traumatic development of AD dementia. Dr. de Guise and colleagues assessed risk factors for developing AD dementia after TBI in a case-control...


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