Home > Neurology > Real-world data fail to show a benefit of edaravone in ALS

Real-world data fail to show a benefit of edaravone in ALS


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Journal
JAMA Neurology
Reuters Health - 10/01/2022 - Treatment with edaravone did not provide a clinically relevant benefit on progression of amyotrophic lateral sclerosis (ALS) over standard therapy alone in a real-world cohort study conducted in Germany. Intravenous edaravone is approved as a disease-modifying drug for ALS, but evidence for efficacy is limited to short-term beneficial effects shown in one study from Japan in a subpopulation in which efficacy was expected, researchers explain in JAMA Neurology. Dr. Simon Witzel of Ulm University and colleagues evaluated the safety and long-term effectiveness of edaravone in an observational study of ALS patients from 12 academic centers affiliated with the German Motor Neuron Disease Network (MND-NET). Disease progression among 116 patients treated for a median of 13.9 months with edaravone did not differ from 116 patients treated for a median of 11.2 months with standard therapy, which included riluzole in the vast majority, the ...


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