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Retinal imaging may predict Alzheimer’s in those at genetic risk


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Journal
JAMA Ophthalmology
Reuters Health - 20/11/2020 - Retinal alterations visible via optical coherence tomography (OCT) in carriers of familial Alzheimer's disease (AD) may well forerun disease onset, according to a cross-sectional study. As Dr. John Miller told Reuters Health by email, "This study has important clinical implications because we identified OCT changes before the onset of cognitive decline in patients with a genetic predisposition to develop Alzheimer's with virtual certainty." "This is important because it minimizes the typical confounders of age and more advanced disease seen in many of the other prior studies from other groups in OCT and Alzheimer's," he added. Dr. Miller of Harvard Medical School, in Boston, and colleagues studied 10 carriers of the PSEN1 E280A mutation who were cognitively unimpaired and 10 healthy family members without the mutation. All were members of the world's largest known autosomal dominant AD kindred, which is centered in Antioquia, Col...


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