Home > Neurology > Reward processing disrupted in Parkinson’s disease, tied to dopamine therapy, psychiatric disorders

Reward processing disrupted in Parkinson’s disease, tied to dopamine therapy, psychiatric disorders


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Journal
Journal of Neurology, Neurosurgery and Psychiatry
Reuters Health - 30/12/2021 - Reward processing impairment in Parkinson's disease (PD) differs depending on the type of reward and the patient's dopamine medication state (on or off), and may underlie neuropsychiatric disorders such as PD-related depression, a systematic review and meta-analysis suggests. "How our brains process positive events ('rewards') is believed to be a key process driving several psychiatric disorders and mediated by dopamine," Dr. Harry Costello of University College London, UK, told Reuters Health by email. "Our analysis aimed to establish whether reward processing was impaired in Parkinson's and how this related to psychiatric symptoms and medication." "Two findings surprised me," he said. "Firstly, how few studies of this kind had looked at specific psychiatric syndromes such as depression in Parkinson's, and secondly, how the effect of dopamine medications seemed to be dependent on what kind of reward processing was being tested."


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